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KMID : 0191120100250121805
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Journal of Korean Medical Science
2010 Volume.25 No. 12 p.1805 ~ p.1808
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Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
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Okutur Kerem
Hasbal Baris
Aydin Kubra
Bozkurt Mustafa
Namal Esat
Oz Buge
Kaynak Kamil
Demir Gokhan
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Abstract
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Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. βhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG. Serum βhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.
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KEYWORD
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Pleomorphic Carcinoma, Lung Neoplasms, Chorionic Gonadotropin, Gynecomastia
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